Skeletal muscle changes in older patients undergoing online hemodiafiltration.

BACKGROUND & AIMS: Skeletal muscle mass (SMM) and function are negatively affected in chronic kidney disease (CKD). SMM and the assessment of muscle strength and functionality are indicators of clinical and nutritional status. We aimed to evaluate older patients undergoing online hemodiafiltration (OL-HDF), using muscle ultrasound (US) to monitor the SMM, correlating findings with strength and physical performance. METHODS: This is a prospective cohort that included patients on OL-HDF, evaluated at admission (T0), 6 months (T1), and 12 months (T2) by anthropometric data, calf circumference (CC) measurement, muscle strength measured by handgrip (HGS) and functionality by gait speed. Muscle US was used for serial assessment of the quantity and quality of SMM during the 12-month follow-up. The main outcome was change in the following muscle parameters: quadriceps muscle thickness (QT), rectus femoris cross-sectional area (RF-CSA), pennation angle (PA) and muscle echogenicity, evaluated by the US. RESULTS: Thirty subjects were included (75.9 ± 7.8 years, 76.7% men). Over time, there was a significant reduction in CC (p < 0.01) in both sexes and gait speed only in men (p < 0.01). The reduction of SMM was observed in both sexes by the assessment of QT and RF-CSA (p < 0.01). There was an increased muscle echogenicity in both men (p < 0.01) and women (p = 0.01). The percentage of SMM loss of the RF-CSA in 12 months was -19.3 ± 6.9% (95% CI: 15.2-23.2; p < 0.01) in men and -23.0 ± 8.2% (95% CI: 12.8-31.1; p < 0.01) in women. CONCLUSION: Muscle US, a bedside, non-invasive, accessible, and inexpensive tool, can be applied for assessment of the accelerated loss of SMM in older patients with CKD on dialysis.

The impact of multivisceral liver resection on short- and long-term outcomes of patients with colorectal liver metastasis: A systematic review and meta-analysis.

The impact of Multivisceral Liver Resection (MLR) on the outcome of patients with Colorectal Liver Metastasis (CRLM) is unclear. The present systematic review aimed to compare patients with CRLM who underwent MLR versus standard hepatectomy regarding short- and long-term outcomes. MLR is a feasible procedure but has a higher risk of major complications. MLR did not negatively affect long-term survival, suggesting that an extended resection is an option for potentially curative treatment for selected patients with CRLM.

The impact of multivisceral liver resection on short- and long-term outcomes of patients with colorectal liver metastasis: A systematic review and meta-analysis

Abstract The impact of Multivisceral Liver Resection (MLR) on the outcome of patients with Colorectal Liver Metastasis (CRLM) is unclear. The present systematic review aimed to compare patients with CRLM who underwent MLR versus standard hepatectomy regarding short- and long-term outcomes. MLR is a feasible procedure but has a higher risk of major complications. MLR did not negatively affect long-term survival, suggesting that an extended resection is an option for potentially curative treatment for selected patients with CRLM.

Safety and effectiveness of mycophenolate mofetil associated with tacrolimus for liver transplantation immunosuppression: a systematic review and meta-analysis of randomized controlled trials.

A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation. This review aimed to evaluate the effectiveness and safety of tacrolimus associated with mycophenolate mofetil (MMF) in patients undergoing liver transplantation. We performed a systematic review and meta-analysis of randomized clinical trials. Eight randomized trials were included. The proportion of patients with at least one adverse event related to the immunosuppression scheme with tacrolimus associated with MMF was 39.9%. The tacrolimus with MMF immunosuppression regimen was superior in preventing acute cellular rejection compared with that of tacrolimus alone (risk difference [RD]=-0.11; p =0.001). The tacrolimus plus MMF regimen showed no difference in the risk of adverse events compared to that of tacrolimus alone (RD=0.7; p=0.66) and cyclosporine plus MMF (RD=-0.7; p=0.37). Patients undergoing liver transplantation who received tacrolimus plus MMF had similar adverse events when compared to patients receiving other evaluated immunosuppressive regimens and had a lower risk of acute rejection than those receiving in the monodrug tacrolimus regimen.

Safety and effectiveness of mycophenolate mofetil associated with tacrolimus for liver transplantation immunosuppression: a systematic review and meta-analysis of randomized controlled trials

A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation. This review aimed to evaluate the effectiveness and safety of tacrolimus associated with mycophenolate mofetil (MMF) in patients undergoing liver transplantation. We performed a systematic review and meta-analysis of randomized clinical trials. Eight randomized trials were included. The proportion of patients with at least one adverse event related to the immunosuppression scheme with tacrolimus associated with MMF was 39.9%. The tacrolimus with MMF immunosuppression regimen was superior in preventing acute cellular rejection compared with that of tacrolimus alone (risk difference [RD]=-0.11; p =0.001). The tacrolimus plus MMF regimen showed no difference in the risk of adverse events compared to that of tacrolimus alone (RD=0.7; p=0.66) and cyclosporine plus MMF (RD=-0.7; p=0.37). Patients undergoing liver transplantation who received tacrolimus plus MMF had similar adverse events when compared to patients receiving other evaluated immunosuppressive regimens and had a lower risk of acute rejection than those receiving in the monodrug tacrolimus regimen.

[Gitelman's Syndrome: from diagnosis to follow-up during pregnancy]. / Síndrome de Gitelman: do diagnóstico ao acompanhamento na gestação

Gitelman's Syndrome (GS) is a rare autosomal recessive salt-wasting nephropathy, classically characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and low blood pressure. Fatigue, muscle weakness and muscle paralysis are common symptoms. Besides the typical electrolyte disturbances, others laboratory findings include hyperreninemia and secondary hyperaldosteronism. Bilateral nephrocalcinosis may occur. The treatment consists of potassium replacement and use of aldosterone antagonists. The best approach to pregnant women with GS is yet to be defined. However, we emphasize the need for ions supplementation, weight control as a clinical tool for assessing the water balance, and frequent monitoring of the fetus and amniotic fluid levels. The surgical risk associated with cesarean section in a patient with GS is not yet defined. Despite the risks related to symptomatic episodes of hypokalemia/hypomagnesemia, GS has a good prognosis when treated properly. Pregnancy imposes the need for more intensive control of the disease, but has a good prognosis for the mother and neonate.

Síndrome de Gitelman: do diagnóstico ao acompanhamento na gestação / Gitelman's Syndrome: from diagnosis to follow-up during pregnancy

Resumo A síndrome de Gitelman (SG) é uma forma rara de nefropatia autossômica recessiva perdedora de sal, caracterizada classicamente por hipocalemia, hipomagnesemia, hipocalciúria, alcalose metabólica e pressão arterial baixa. Fadiga, fraqueza muscular e paralisia muscular estão entre seus sintomas mais comuns. Além dos distúrbios eletrolíticos típicos, outros achados laboratoriais incluem a hiperreninemia e o hiperaldosterismo secundário. Nefrocalcinose bilateral pode ocorrer. O tratamento consiste basicamente na reposição de potássio e uso de antagonistas da aldosterona. A melhor abordagem para gestantes portadoras de SG ainda está por ser definida. Entretanto, enfatiza-se a necessidade de suplementação dos íons, o controle do peso como ferramenta clínica de avaliação do balanço hídrico e a monitorização frequente do feto e dos níveis de líquido amniótico. O risco cirúrgico associado à cesariana em paciente com SG não está definido. Apesar dos riscos associados às crises sintomáticas de hipocalemia/hipomagnesemia, a SG apresenta bom prognóstico quando adequadamente tratada. A gravidez impõe a necessidade de controle mais intenso da doença, mas apresenta bom prognóstico para o binômio materno-fetal.

Abstract Gitelman's Syndrome (GS) is a rare autosomal recessive salt-wasting nephropathy, classically characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and low blood pressure. Fatigue, muscle weakness and muscle paralysis are common symptoms. Besides the typical electrolyte disturbances, others laboratory findings include hyperreninemia and secondary hyperaldosteronism. Bilateral nephrocalcinosis may occur. The treatment consists of potassium replacement and use of aldosterone antagonists. The best approach to pregnant women with GS is yet to be defined. However, we emphasize the need for ions supplementation, weight control as a clinical tool for assessing the water balance, and frequent monitoring of the fetus and amniotic fluid levels. The surgical risk associated with cesarean section in a patient with GS is not yet defined. Despite the risks related to symptomatic episodes of hypokalemia/hypomagnesemia, GS has a good prognosis when treated properly. Pregnancy imposes the need for more intensive control of the disease, but has a good prognosis for the mother and neonate.

Enterorrhagia due to pelvic hematoma after femoral catheterization / Enterorragia por hematoma pélvico após cateterismo femoral

Arterial puncture, better known as catheterization, has become an important diagnostic tool in recent years. For its realization, generally the option is the Seldinger technique, which is considered today the safest and most often used procedure. This technique allows the insertion of large-caliber or multiple-lumen catheters in the vessel. Arterial catheterization helps in several exams, for instance, mesenteric angiography and cardiac output assessment, and contributes in cineangiocoronariography procedures. We report the case of a 67-year-old male patient who was submitted to cineangiocoronariography and evolved with enterorrhagia due to pelvic hematoma. Throughout the patient's care, a conservative treatment was chosen. The progression of the patient was uneventful and then the patient was discharged. It is very hard to determine which arterial segment was injured; however, as the hematoma was located predominantly in the pelvic region, it is believed that an injury occurred at the internal iliac artery, or directly at the bifurcation of the common iliac artery. Furthermore, it is assumed that a catheter kinking occurred during its progression, due to any tortuosity or to the presence of an atheromatous plaque, thus favoring the occurrence of the more distal lesion, rather than the proximal one. We decided to report this case because of its high degree of rarity, with a scarce number of papers in the literature related to the topic. Thus, with the description of this report we believe that other medical teams will have facilitated their decision-making process, when facing a similar case. (AU)

A punção arterial, mais conhecida como cateterização, tornou-se uma importante ferramenta diagnóstica nos últimos anos. Para sua realização geralmente opta-se pela técnica de Seldinger que é considerada a mais segura e utilizada na atualidade. Esta técnica permite a inserção de cateteres de grosso calibre e ou de múltiplos lúmens em vasos. A cateterização arterial auxilia na realização de exames como arteriografia mesentérica, avaliação do débito cardíaco, além de contribuir na realização da cineangiocoronariografia (CATE). Relata-se um caso de que um paciente masculino de 67 anos que foi submetido ao CATE e evoluiu com enterorragia devido ao hematoma pélvico. Em todo momento foi optado por tratamento conservador. A evolução do paciente ocorreu sem intercorrências e entao o paciente foi de alta. Dificilmente é possível precisar qual segmento arterial foi lesado, entretanto, como o hematoma localizou-se predominantemente na regiao pélvica, acredita-se que ocorreu uma lesão da artéria ilíaca interna ou logo na bifurcação da artéria ilíaca comum. Ademais, supõe-se que aconteceu uma dobra no cateter durante a sua progressão devido a alguma tortuosidade ou mesmo pela presença de placas ateromatosas. Favorecendo, dessa forma, a ocorrência da lesao mais distal e nao proximal. Optou-se por relatar tal caso devido ao alto grau de raridade, e consequentemente, nota-se que há poucos achados na literatura relacionados ao tema. Dessa forma, com a descrição deste relato podem-se ajudar equipes médicas a tomarem condutas quando deparadas com um caso semelhante. (AU)

Nutritional repercussions in patients submitted to bariatric surgery.

BACKGROUND: Few studies evaluated the association between nutritional disorders, quality of life and weight loss in patients undergoing bariatric surgery. AIM: To identify nutritional changes in patients undergoing bariatric surgery and correlate them with weight loss, control of comorbidities and quality of life. METHOD: A prospective cohort, analytical and descriptive study involving 59 patients undergoing bariatric surgery was done. Data were collected preoperatively at three and six months postoperatively, evaluating nutritional aspects and outcomes using BAROS questionnaire. The data had a confidence interval of 95%. RESULTS: The majority of patients was composed of women, 47 (79.7%), with 55.9% of the series with BMI between 40 to 49.9 kg/m(²). In the sixth month after surgery scores of quality of life were significantly higher than preoperatively (p<0.05) and 27 (67.5 %) patients had comorbidities resolved, 48 (81.3 %) presented BAROS scores of very good or excellent. After three and six months of surgery 16 and 23 presented some nutritional disorder, respectively. There was no relationship between the loss of excess weight and quality of life among patients with or without nutritional disorders. CONCLUSION: Nutritional disorders are uncommon in the early postoperative period and, when present, have little or no influence on quality of life and loss of excess weight.

Nutritional repercussions in patients submitted to bariatric surgery / Repercussões nutricionais em pacientes submetidos à cirurgia bariátrica

BACKGROUND: Few studies evaluated the association between nutritional disorders, quality of life and weight loss in patients undergoing bariatric surgery. AIM: To identify nutritional changes in patients undergoing bariatric surgery and correlate them with weight loss, control of comorbidities and quality of life. METHOD: A prospective cohort, analytical and descriptive study involving 59 patients undergoing bariatric surgery was done. Data were collected preoperatively at three and six months postoperatively, evaluating nutritional aspects and outcomes using BAROS questionnaire. The data had a confidence interval of 95%. RESULTS: The majority of patients was composed of women, 47 (79.7%), with 55.9% of the series with BMI between 40 to 49.9 kg/m². In the sixth month after surgery scores of quality of life were significantly higher than preoperatively (p<0.05) and 27 (67.5 %) patients had comorbidities resolved, 48 (81.3 %) presented BAROS scores of very good or excellent. After three and six months of surgery 16 and 23 presented some nutritional disorder, respectively. There was no relationship between the loss of excess weight and quality of life among patients with or without nutritional disorders. CONCLUSION: Nutritional disorders are uncommon in the early postoperative period and, when present, have little or no influence on quality of life and loss of excess weight. .

RACIONAL: Poucos estudos avaliam a associação entre distúrbios nutricionais, qualidade de vida e perda de peso em pacientes submetidos à cirurgia bariátrica. OBJETIVO: Identificar alterações nutricionais em pacientes submetidos à cirurgia bariátrica e correlacioná-las com perda de peso, controle de comorbidades e qualidade de vida. MÉTODO: Estudo de coorte, prospectivo, analítico e descritivo envolvendo 59 pacientes submetidos à cirurgia bariátrica. Os dados foram coletados no pré-operatório e aos três e seis meses pós- operatórios, quantificando aspectos nutricionais e utilizando o Bariatric Analysis and Reporting Outcomes System (BAROS) como ferramenta de sucesso. Os dados usaram intervalo de confiança de 95%. RESULTADOS: O total de mulheres foi 47 (79,7%), sendo 55,9% com IMC entre 40-49,9 kg/m². No sexto mês depois da operação os escores de qualidade de vida foram significativamente maiores do que no pré-operatório (p<0,05) e 27 (67,5%) pacientes tinham todas comorbidades resolvidas, 48 (81,3%) apresentaram conceito BAROS muito bom ou excelente. Após três e seis meses 16 e 23 pacientes apresentaram algum distúrbio nutricional, respectivamente. Não houve relação entre a perda do excesso de peso e qualidade de vida entre pacientes com ou sem distúrbio nutricional. CONCLUSÃO: os distúrbios nutricionais são pouco frequentes no pós-operatório precoce e, quando presentes, têm pouca ou nenhuma influência na qualidade de vida e na perda do excesso de peso. .

Incidence of angiolymphatic invasion in colorectal cancer

Angiolymphatic invasion (ALI) in colorectal cancer (CRC) is considered as an important independent prognostic factor and may influence therapeutic decisions. OBJECTIVE: This aim of the study is to find the incidence of ALI in histopathological reports of surgical specimens from patients who underwent surgical treatment of colorectal adenocarcinoma. RESULTS: One hundred and twenty seven patients were male (50.6%) and the mean age was 60 years old. The overall incidence of ALI was 44.6%, and there was a significant association with age (p=0.016), lymph node involvement (N) (p<0.00001) and tumor differentiation (p=0.0039). CONCLUSION: There was a higher probability of finding ALI in younger patients, with a higher number of lymph node metastases and a lower tumor differentiation. (AU)

A invasão angiolinfática (LVI) no câncer colorretal (CCR) é considerada um importante marcador independente de prognóstico e pode influenciar em decisões terapêuticas. OBJETIVO: Encontrar a incidência de LVI através de laudos histopatológicos de peças operatórias de pacientes submetidos a tratamento cirúrgico de câncer colorretal, por adenocarcinoma. RESULTADOS: A média de idade encontrada foi de 60,08 anos. Cento e vinte sete pacientes eram do sexo masculino (50,6%). A incidência global de LVI foi de 44,6% e houve associação significativa com a idade (p=0,016), o grau de acometimento linfonodal (N) (p<0,00001) e o grau de diferenciação (p=0,0039). CONCLUSÃO: Há uma maior probabilidade de encontrarmos LVI em pacientes mais novos, com um número maior de linfonodos acometidos e um menor grau de diferenciação celular. (AU)

Vigilância em saúde do trabalhador rural: um instrumento para o programa de saúde da família / Active search to rural workers: an instrument heaith family program

Objetivos: investigar a presença de cargas de trabalho em famílias de trabalhadores rurais. Método: um roteiro de pesquisa de cargas de trabalho foi aplicado em zona rural agrícola, por acadêmicos de medicina e profissionais de saúde da família. Resultados: foram identificados problemas de origem ambiental, sanitária e decorrentes da organização de processos de trabalho. O roteiro e os resultados obtidos foram referendados pela equipe rural de saúde da família. Conclusão: propõe-se um instrumento de coleta de dados complementar para identificação de demandas de saúde decorrentes do trabalho rural.

Purpose: To investigate the presence of occupational rural risks and their consequences to family health. Methods: The workers answered a questionary about the work burden. Resulte: Several occupational risks were identified in agricultural work, originated from the environment and sanitary and work process organization. The results were analyzed by a Family Health Program team. Conclusion: This questionary can be a supplementary instrument to other parameters aiming the identification of health problems related to the work in rural area.